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Abstract #2218

Application of High B-value Diffusion-Weighted Imaging in Defining High-grade Glioma Infiltration Regions

Chunhui Jiang1, Jian Wang2, Juan Ma2, Abudureheman Yibanu2, and Chen Liu3

1MRI Room,Department of Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China, 2MRI Room,Department of Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, 3Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University

Objective To evaluate the role of the ADC value in patients with high-grade glioma (WHO III-IV) using high B-value diffusion weighted imaging (DWI), as a potential noninvasive quantitative index in defining the boundary of glioma. Methods 25 cases of surgical pathologically confirmed glioma underwent the DWI scan with b=1000 and 3000s/mm2 respectively in a 3T MR scanner. The ADC values of the glioma substantial zone, cerebral parenchyma within 0-10/10-20mm radium and the cerebral parenchyma of the opposite sphere are statistically analyzed by SPSS17.0. Results When b=1000 and 3000 s/mm2, the difference in the ADC values of the tumor and the 0-10mm region had no statistical significance(P>0.05). When b-value = 1000 s/mm2, there is statistically valid difference among ADC values of 10-20mm area, lesions and comparing group (P<0.05); When b-value =3000 s/mm2, there is no statistically valid difference among ADC values of 10-20mm area and lesions(P>0.05). The ADC value of 10-20mm area is validly lower than the lesions. Conclusion The ADC value in high B value DWI scan indicating that the ADC value is more sensitive in quantitatively analyzing the infiltration zone of glioma relative to the low B value DWI scan.

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