The relationship between three functional parameters related to cell density, ADC, R1N, and ve, were examined in 12 patients with vestibular schwannomas pre- and post- anti-angiogenic therapy. 3D maps of R1N obtained with variable flip angle images, and ve derived from DCE-MRI were compared to 3D maps of ADC. The tumor mean values of ADC, R1N and ve showed correlation to each other before bevacizumab treatment. This correlation was lost after three-months of treatment. Both R1N and ADC displayed power in prediction of treatment. R1N showed more sensitive to anti-angiogenic therapy induced changes in VS than ADC or ve.