With an objective neuroimaging data-driven method using agglomerative hierarchical clustering analysis, two patterns of cortical matter changes among 58 first episode bipolar manic adolescents has been identified. And the clinical feature especially the intelligence quotient was corresponding to the subtyping among these patients. While the effect of medication and illness duration have been minimized, our findings provided new evidence indicating the existence of two neurobiologically distinct subgroups of patients with first episode bipolar mania, which may reflect qualitatively distinct genetic influences or neurodevelopmental alterations.
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