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Abstract #2242

Remitted and non-remitted patients with schizophrenia show distinct patterns of white matter tract alterations

Jing-Ying Huang1, Chih-Min Liu2,3, Tzung-Jeng Hwang2,3, Yu-Jen Chen1, Yung-Chin Hsu1, Hai-Gwo Hwu2,3, and Wen-Yih Isaac Tseng1,3,4,5

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan, 3Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, 4Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, 5Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To investigate the relations between white matter tracts and treatment outcome, we performed diffusion spectrum imaging (DSI) and whole brain tract-based automatic analysis (TBAA) comparisons of the tract integrity over the whole brain. As compared with health controls, non-remitted patients showed reduced integrity in 7 fiber tract bundles, whereas remitted patients only showed 4 fiber tract bundles. When comparing with remitted patients, non-remitted patients showed reduced integrity in the same 7 fiber tract bundles as those found in comparison with healthy controls. Our results support that remitted and non-remitted patients had distinctly different severity of tract alterations.

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