Around 200,000 veterans (up to 32% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), which is characterized by multiple deficits in cognitive, emotion, somatosensory and pain domains. In this study we examined 22 GWI patients and 30 age-matched controls with resting state fMRI (rsFMRI) in order to map impairments in brain function networks in GWI with graph theory based advanced network analysis methods. Results show widespread impairments in functional connectivity of cognition, affective, somatosensory and pain processing brain function networks in GWI consistent with multi-symptom nature of the illness.
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