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Abstract #2286

Spherical Wavelets based Study of Multi-scale Cortical Folding in Infants

Dingna Duan1,2, Islem Rekik1, Shunren Xia2, Weili Lin1, John H Gilmore3, Dinggang Shen1, and Gang Li1

1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, People's Republic of China, 3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Examining cortical folding development at various scales may help better understand brain cognition and motor functions. We propose a curvature-based multi-scale method using spherical wavelets to study the longitudinal changes of cortical folding during infancy. We applied our method on 219 longitudinal MR images from 73 healthy infants at 0, 1, and 2 years of age. We reveal scale-specific and region-specific developmental patterns of infant cortical folding. Specifically, at coarser levels, many primary folds flatten out; while at finer levels, the majority of the minor folds become more convoluted, providing new insights into early brain development.

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