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Abstract #2295

Constrained spherical deconvolution has the potential to better characterize neuronal structure in Cerebral Palsy before and after therapy.

Adam Scott Bernstein1, Amber L. Pokorney2, Harry Hu2, Jeffrey H. Miller2, Burris Duncan3, and Theodore Trouard1

1Biomedical Engineering, University of Arizona, Tucson, AZ, United States, 2Phoenix Children's Hospital, Phoenix, AZ, United States, 3Pediatrics, University of Arizona, Tucson, AZ, United States

Cerebral Palsy is a nonprogressive condition that results in very heterogenous motor and other deficits that usually arises during the peripartum period. Many studies have tried to characterize changes in the brain of patients with cerebral palsy using fractional anisotropy and tractography based on diffusion tensor imaging, but few have utilized any of the more recent techniques, such as constrained spherical deconvolution, to more adequately account for complex fiber structures. These more recent techniques also offer more descriptive scalar measures of microstructure, such as apparent fiber density, that can be used to better characterize changes in neural structure.

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