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Abstract #2303

Study on the brains of perinatally HIV infected asymptomatic adolescents by intravoxel incoherent motion diffusion weighted imaging

Jing Zhang1, Yunfei Zha2, Guangyao Wu3, and GE healthcare China4

1Department of Radiology, Remin Hospital of Wuhan University, Wuhan, People's Republic of China, 2Remin Hospital of Wuhan University, wuhan, People's Republic of China, 3Zhongnan Hospital of Wuhan University, People's Republic of China, 4GE healthcare China, Beijing, People's Republic of China

IVIM diffusion is applied to detect the changes in the brain of perinatally HIV-infected adolescents in our work. 18 children with HIV positive and 17 HIV negative children underwent MRI scan on a 3.0T whole body scanner including multi-b diffusion imaging. The IVIM parameters (D, D*and f ) were obtained by fitting using MITK software. Correlation of IVIM parameters and CD4+T cell counts, CD4/CD8 ratio were analyzed. D* value of caudate nucleus and frontal white matter decreased significantly in HIV positive children and the changes of D* were positively correlated with CD4+T cell counts and CD4/CD8 ratio. However´╝îD and f were not statistically significant. IVIM improves on the detection brain damage in HIV infected asymptomatic adolescents as compared to conventional DWI.

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