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Abstract #2313

Detection of subtle white matter alterations in migraine using diffusion kurtosis imaging

Yu-Shiuan Liang1, Ming-Ting Wu2, Ching-Sen Shih3, and Ming-Chung Chou1,4

1Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, 2Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3Department of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 4Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung, Taiwan

Migraine subjects were demonstrated to exhibit white matter alterations detected by diffusion tensor imaging (DTI). Due to the Gaussian assumption of water distribution employed in DTI technique, the measured diffusivity may not be accurate and may hinder the detection of white matter alterations. Diffusion kurtosis imaging (DKI) was demonstrated to better characterize white matter alterations without Gaussian assumption and has not been utilized to detect white matter alterations in migraine subjects. This study performed DKI to detect microstructural white matter alterations and demonstrated that diffusion kurtosis parameters were more sensitive to subtle white matter alterations than diffusion tensor parameters.

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