Abstract #2318

No Evidence of Increased Iron Accumulation in the Deep Gray Matter of Patients with Amyotrophic Lateral Sclerosis (ALS)

Florian Borsodi¹, Valeriu Culea¹, Christian Langkammer¹, Michael Khalil¹, Lukas Pirpamer¹, Stefan Quasthoff¹, Christian Enzinger^1,2, Franz Fazekas¹, and Stefan Ropele¹

¹Department of Neurology, Medical University of Graz, Graz, Austria, ²Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria

Iron accumulation in deep gray matter occurs during normal aging, but has also been observed in several neurodegenerative diseases. To investigate if this still holds true for ALS, we aimed at assessing the iron content in deep gray matter structures of 24 ALS patients with quantitative susceptibility mapping and its relation to 28 controls. We did not find any significant differences in iron levels between ALS patients and controls. This may indicate that iron accumulation in deep gray matter is a specific feature that is not associated with neurodegenerative diseases in general, but rather reflects more specific degenerative processes.

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