We used advanced MR imaging methods to investigate neurophysiological changes following major burns injury in a cohort of patients with reduced cognitive function compared to age and sex-matched controls. In this preliminary study, small regions of increased connectivity were observed in patients in two brain networks extracted from resting-state fMRI data using ICA. However, the significance of these results is unclear given the broad range of neurological functions implicated by the cognitive deficits. Furthermore, we found no significant difference between patients and controls for TBSS, volumetric analysis and MR spectroscopy. SWI indicated large areas of microbleeds in one patient.