Abstract #2346

Global Change of Intrinsic Functional Networks as an Imaging biomarker of Alzheimer’s disease

Chia-Feng Lu^1,2,3, Wen-Jin Hsieh^1,4, Yu-Chieh Jill Kao^1,2, Paul Blakeley^1,5, Fei-Ting Hsu^1,4, Hua-Shan Liu^1,6, Ping-Huei Tsai^1,2,4, Li-Chun Hsieh^1,4, and Cheng-Yu Chen^1,2,4

¹Translational Imaging Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁵Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan, ⁶School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan

The change of whole-brain connectivity during resting state can be a reliable feature in discriminating patients with Alzheimer’s disease (AD) from patients with mild cognitive impairment and cognitively healthy elders. Significant correlations between resting-state functional connectivity and cognitive decline measured by Mini-Mental State Examination (MMSE) were further identified.

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