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Abstract #2349

Using Calibrated Proton Density Imaging to Measure Blood-Brain Partition Coefficient in Aging and Alzheimer's Disease Mice

Scott William Thalman1, David Powell2,3, Andrew Shen4, Anika M.S. Hartz4,5, and Ai-Ling Lin1,4,6

1Biomedical Engineering, University of Kentucky, Lexington, KY, United States, 2Biomedical Engineering, University of Kentucky, KY, United States, 3Magnetic Resonance Imaging and Spectroscopy Center, 4Sanders-Brown Center on Aging, University of Kentucky, KY, United States, 5Molecular and Biomedical Pharmacology, University of Kentucky, 6Pharmacology and Nutritional Sciences, University of Kentucky

In this study we determine the blood-brain partition coefficient (BBPC) in aging C57Bl6/N mice and the transgenic 129S6/Tg2576 mouse model of Alzheimer’s disease using a calibrated proton density imaging approach. Aging mice demonstrate a 5.5% reduction in BBPC compared to young mice (0.94±0.04 mL/g vs 0.99±0.04 mL/g, p = 0.02), however Tg2576+ mice preliminarily demonstrate an elevated BBPC compared to wild-type controls (01.03±0.04 mL/g vs 1.00±0.05 mL/g). These high quality BBPC maps acquired much faster than previously reported could potentially be used to correct cerebral blood flow measurements derived from arterial spin labeling.

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