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Abstract #2360

Altered Hippocampal Functional Connectivity with PCC in SCI, MCI and AD

Hui Zhang1, Joseph Shiu-Kwong Kwan2, Pui-Wai Chiu1,3, Edward S. Hui1, Queenie Chan4, and Henry Ka-Fung Mak1,5,6

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, 3State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, 4MR Clinical Science, Philips Healthcare, Hong Kong, Hong Kong, 5State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, 6Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

Brain imaging research has elucidated the structural and functional changes at the clinical stages of AD and MCI, however, the characteristics of resting-state functional connectivity of SCI are largely unstudied. Hippocampus is among the first regions targeted by AD pathology. In this study, we employed resting state fMRI to study the connectivity between hippocampus and posterior cingulate cortex in SCI, MCI and AD groups. In the preliminary results, the connectivity between hippocampus and PCC in SCI was found stronger than control and other two neurodegenerative groups which may suggest that compensatory mechanisms providing preserved hippocampal pathway in SCI.

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