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Abstract #2375

White matter hyperintensity burden assessed ante-mortem and post-mortem on the same older adults

Arman Kulkarni1, Arnold M. Evia1, Julie A. Schneider2,3,4, David A. Bennett2,3, and Konstantinos Arfanakis1,2,5

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States, 3Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, 4Department of Pathology, Rush University Medical Center, Chicago, IL, United States, 5Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, United States

White matter hyperintensities (WMH) are commonly observed in brain MR images of older adults. Recently, more and more research studies assess WMH burden using ex-vivo MRI, aiming at directly linking WMH to the underlying neuropathologies detected at autopsy. The purpose of this work was twofold: 1) to investigate the relationship between WMH burden assessed in-vivo and ex-vivo on the same older adults, and 2) to test the hypothesis that WMH burden assessed ex-vivo is higher than that assessed in-vivo for longer ante-mortem intervals (AMI) (i.e. from in-vivo MRI to death).

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