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Abstract #2408

Carbon fiber electrodes for single-unit recording combined with artifact-free MRI

Miguel Roberto Chuapoco1, Ben Andrew Duffy2, Hyun Joo Lee2, ManKin Choy2, and Jin Hyung Lee2,3

1Department of Chemical Engineering, Stanford University, Stanford, CA, United States, 2Department of Neurology and Neurological Sciences, Stanford University, 3Departments of Bioengineering, Neurosurgery, Electrical Engineering, Stanford University, Stanford University

Combining unit recording and fMRI is a powerful method that allows for interrogation of the brain at the cellular and network level. However, implanted metal recording electrodes produce susceptibility artifacts that distort MR images. Here, we fabricate single carbon-fiber electrodes and implant them into rat hippocampus and use an agarose phantom to quantify its MR distortion. These carbon-fiber electrodes record from a single unit in CA1 and distort a significantly lower volume of voxels compared to metal electrodes. These results lay the groundwork for an electrode design that can be used for single-unit recording and fMRI in same subjects.

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