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Abstract #2450

The role of serotonin in cerebral blood flow and oxygen metabolism in migraine

Kenneth M Jackson1, Steven C Liu1, Christy Jackson2, Richard B Buxton1, and David Dubowitz1

1Radiology, University of Californai San Diego, La Jolla, CA, United States, 2Neurology, Scripps Clinic, La Jolla, CA, United States

We examined the CBF and CMRO2 changes that accompany menstrual migraine, and evaluated the response to sumatriptan to determine the role of serotonin in migraine pathophysiology. Migraine is accompanied by a decline in global CBF and CMRO2 that appears to be serotonin-mediated. There is also a decline in stimulus-dependent CBF to a visual stimulus, that appears to also involve serotonin, but acts differently from the global responses. A decline in visual stimulus-dependent CMRO2 is not serotonin mediated, and appears to follow the normal variation in stimulus-dependent CMRO2 response that changes with normal menstrual cycle.

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