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Abstract #2465

Assessment of cerebral perfusion autoregulation impairment – An experimental setup to quantify regional cerebral blood flow (CBF) in normal and head down tilt position

Dhaval B Shah1, Michael G Dwyer1, Brian Koyn2, Nicola Bertolino1, Cheryl Knapp3, Barry S Willer4, John J Leddy5, Robert Zivadinov1,3, and Ferdinand Schweser1,3

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 2Health Sciences Fabrication Shop, Department of Medicine,Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 3MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 4Department of Psychiatry,Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, 5Department of Orthopedics,Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

Previous studies using Transcranial Doppler have shown that cerebral ischemia, head trauma, and cerebral perfusion pressure are associated with an impairment of the cerebral autoregulation (CA) and alteration of perfusion. However, simulating perfusion changes and quantifying them with higher specificity repetitively has been a challenge in clinics. We propose a clinical experimental setup for an MRI-based head down tilt protocol to study the CA by quantifying perfusion. We demonstrate local perfusion change results in healthy controls and a patient.

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