Meeting Banner
Abstract #2484

Hierarchical organization of functional networks in patients with Parkinson’s Disease

Karthik Sreenivasan1, Virendra Mishra1, Zhengshi Yang1, Xiaowei Zhuang1, Sarah Banks1, Dietmar Cordes1,2, Ryan R Walsh1, and Karthik Sreenivasan1

1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

Earlier studies using fMRI have shown the existence of a modular structure for different brain networks. However, no information exist about hierarchical modular structure of functional connectivity networks in patients with Parkinson’s disease(PD). Using percolation analysis, we found a shift in the hierarchical modular structure of functional connectivity networks in patients with PD. A shift in the modules in caudal-rostral direction in the PD group of motorically affected patients, alongside rearrangement of connector hubs and provincial hubs in PD patients was observed. Potential application of network properties observed here, as predictors of subsequent disease progression is currently being investigated.

This abstract and the presentation materials are available to members only; a login is required.

Join Here