Problem: The clinical utility of myelin water fraction (MWF) mapping based on multi-echo-spin-echo (MESE) T2-relaxometry is prohibitively slow (~90-120 minutes for acquisition matrix 128x128x50; TR 3s). MWF-values from T2-prep based approach and mcDESPOT (Multicomponent-driven-equilibrium-single-pulse-observation-of-T1-and-T2) matches poorly with MESE based quantification.
Methods: We compare GRASE (Gradient-and-Spin-Echo) based MWF quantifications against those from MESE and compare our algorithm against current state of the art. 3D non-selective GRASE, MESE were optimized. Implemented post-processing method utilizes spatial correlations in 3D local neighborhoods to improve noise stability, while simultaneously accounting for stimulated echo contributions.
Results & Conclusions: Results demonstrate good consistency between both sequences.