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Abstract #2525

Gradient and Spin Echo (GRASE) as an Alternative to Multi Echo Spin Echo (MESE) acquisition for Myelin Water Fraction Imaging

Dushyant Kumar1, Hari Hariharan1, Jens Fiehler2, Susanne Siemonsen2, Jan Sedlacik2, and Ravinder Reddy1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Klinik und Poliklinik f├╝r Neuroradiologische Diagnostik und Intervention, Universit├Ątsklinikum Hamburg-Eppendorf, Hamburg, Germany

Problem: The clinical utility of myelin water fraction (MWF) mapping based on multi-echo-spin-echo (MESE) T2-relaxometry is prohibitively slow (~90-120 minutes for acquisition matrix 128x128x50; TR 3s). MWF-values from T2-prep based approach and mcDESPOT (Multicomponent-driven-equilibrium-single-pulse-observation-of-T1-and-T2) matches poorly with MESE based quantification.

Methods: We compare GRASE (Gradient-and-Spin-Echo) based MWF quantifications against those from MESE and compare our algorithm against current state of the art. 3D non-selective GRASE, MESE were optimized. Implemented post-processing method utilizes spatial correlations in 3D local neighborhoods to improve noise stability, while simultaneously accounting for stimulated echo contributions.

Results & Conclusions: Results demonstrate good consistency between both sequences.

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