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Abstract #2537

Gaining insights into Multiple Sclerosis Lesion Characteristics from Brain Tissue Microstructure Information: A multi-compartment T2 relaxometry Approach

Sudhanya Chatterjee1, Olivier Commowick2, Simon K. Warfield3, and Christian Barillot4

1VisAGeS, IRISA U746, Universite de Rennes-1, Rennes, France, 2VisAGeS Inserm U746, IRISA, Inria, Rennes, France, 3Boston Children’s Hospital, Boston, MA, United States, 4VisAGeS, INRIA/IRISA, Inserm U746, CNRS, Rennes, France

Clinical trends and Pathogenetic ways of onset and progression of Multiple Sclerosis (MS) in patients suggest that MS is a highly heterogeneous disease. MS is predominantly a White Matter (WM) disease, which is mainly composed of myelinated axons and neuroglia type cells. Demyelination and axonal loss characterize the condition of MS in a patient. However, they follow varying trends in patients. In this work, we propose a method in which T2 relaxometry data is used to obtain a quantitative brain tissue microstructure information. This information is then studied to check its corroborations with pathogenetic understanding of MS in literature.

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