Abstract #2558

mcDESPOT-derived tissue parameters in the brainstem and corpus callosum of MS and NMOSD patients with cervical cord lesions

Lisa Eunyoung Lee¹, Anna J.E Combes², Jillian Chan¹, Robert Carruthers¹, Jacqueline Palace³, Lucy Matthews³, Anthony Traboulsee¹, and Shannon Kolind^1,4

¹Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ²Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, ³Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are demyelinating central nervous system disorders that may present with some overlapping clinical symptoms but differ pathophysiologically. We used tissue-specific quantitative measures, produced by mcDESPOT, to characterize tissue pathology in MS and NMOSD groups compared to healthy controls. We observed decreased myelin water fraction, increased T2 of intra/extracellular water, increased cerebrospinal volume fraction, and increased myelin water residence time in the brainstem and corpus callosum of MS and NMOSD subjects, compared to controls. These sensitive advanced MRI measures could provide an improved understanding of MS and NMOSD pathogenesis.

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