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Abstract #2563

Chronic pain-related sexual dimorphism in gray matter density: A whole-brain voxel-based morphometric study on Osteoarthritis patients

Marianne M Drabek1,2, Diane Reckziegel1,2, Cottam J William1,2, Xingfeng Li2, Nadia Frowd1, Hamza Alshuft1,2,3, Brigitte Scammell1, Thomas Kurien1, and Dorothee P Auer1,2

1University of Nottingham, Arthritis Research UK Pain Centre, Nottingham NG7 2RD, England, Nottingham, United Kingdom, 2University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham NG7 2RD, England, Nottingham, United Kingdom, 3Neurosurgery, Nottingham University Hospitals, Nottingham, United Kingdom

Chronic pain is a major problem for society and further studies are needed to understand pain-related developments. In particular, controversy exists over the pattern of pain-related structural changes in the brain. The current morphometric study addresses inconsistencies through a large sample of chronic osteoarthritis knee pain patients and healthy volunteers scanned at a single-site, allowing to differentiate sex effects which are usually ignored. We found significantly decreased gray matter density in pain patients in several brain regions, amongst which the left planum temporale which was driven by the female subjects and has not been mentioned in relation to pain before.

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