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Abstract #2568

A Pseudo-Longitudinal Study of the Lifespan Neuroanatomical Changes based on a Large-scale Imaging Data

LIN SHI1, PEIPENG LIANG2,3,4, YISHAN LUO3,4, KAI LIU3, Vincent CT MOK1, Winnie CW CHU3, DEFENG WANG3,4, and KUNCHENG LI2

1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China, 3Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 4Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, People's Republic of China

Understanding how brain changes over the lifetime provides the basis for new insights into neurophysiology and neuropathology. In this study, we carried out a pseudo-longitudinal study based on large-scale cross-sectional high-resolution brain MR data atlas Chinese2020 to model the brain morphological changes in Han Chinese adulthood. Our results found some novel age-related neuroanatomical changes in a standardized brain space via temporal-spatial statistical brain templates.

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