In this retrospective study, we examined the feasibility and safety of magnetic resonance imaging (MRI)-guided percutaneous cryoablation of regional nodal metastases in the setting of prostate cancer. The study cohort comprised eight patients with biochemically recurrent prostate cancer who had undergone prior prostatectomy and radiotherapy, thereby limiting their ability to receive further radiation to regional nodes. Technical success was achieved in all cases and there were no procedure-related complications. Our data suggest that MRI-guided cryoablation offers a feasible alternative therapy for local control of metastatic lymph nodes. Further prospective investigation is warranted to assess short- and long-term local efficacy.