The widely used MOLLI (MOdified Look-Locker Inversion recovery) T1 mapping approach underestimates T1 values as a function of several factors, including off-resonance frequency. Native T1 and matched off-resonance frequency (Δω) maps were acquired in 24 subjects as part of a study of patients with kidney disease (3T field strength). Δω within individuals had an average range 133±43Hz, and Δω was significantly correlated with underestimation of native T1, in good agreement with Bloch equation simulations. ~50% of slices had relatively large (75-150 Hz) off-resonance frequencies, for which T1 errors ranged from -25ms to -150ms.
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