We developed a novel ASL-based flow imaging (ASL-Flow) with modified flow-sensitive alternating inversion recovery technique and Look-Locker sequence to evaluate cardiovascular hemodynamics and valvular dysfunction. We validate that time-intensity curves of pulmonary artery form ASL-Flow matches for time-velocity curves from 2D phase-contrast MRI. ASL-Flow can visualize more clearly regurgitateion and stenotic jet in valvular diseases than standard cine imaging. The scan time for ASL-Flow is short (15 seconds/slice), and the image reconstruction needs no special software; therefore, this is easy to clinically use. We promise that ASL-Flow is a feasible non-contrast imaging to detect hemodynamics abnormality in structural heart disease.