We investigated global and regional myocardial wall motion abnormalities using strain-encoded (SENC) MRI in comparison with late gadolinium enhancement (LGE) in patients with systemic sarcoidosis. Fourteen patients were retrospectively evaluated. We found that global strain assessed using SENC MRI correlated well with global left ventricular (LV) dysfunction and the extent of LGE. In addition, regional longitudinal strain significantly decreased in segments with >10% LGE. SENC MRI has the potential to detect global and regional LV dysfunction and to predict the extent of LGE.