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Abstract #2901

Combined analysis of ten DW-MRI studies demonstrates excellent repeatability of apparent diffusion coefficient estimates in extra-cranial soft-tissue tumours

Jessica M Winfield1,2, Nina Tunariu1,2, Mihaela Rata1,2, Keiko Miyazaki1,2, Neil P Jerome1,2, Michael Germuska1,2,3, Matthew D Blackledge1,2, David J Collins1,2, Johann S de Bono4,5, Timothy A Yap4,5, Nandita M deSouza1,2, Simon J Doran1,2, Dow-Mu Koh1,2, Martin O Leach1,2, Christina Messiou1,2, and Matthew R Orton1,2

1Cancer Research UK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, 2MRI Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 3Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 4Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom, 5Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom

Repeatability of ADC estimates from ten diffusion-weighted MRI studies in extra-cranial soft tissues (nine patient studies and one healthy volunteer study, with a total of 111 subjects) were analysed in combination using the Radiological Society of North America (RSNA) Quantitative Imaging Biomarkers Alliance (QIBA) framework for assessment of technical performance of imaging biomarkers, in order to investigate factors affecting ADC repeatability. Coefficient of variation was between 2 and 7% for all studies, with no marked differences between imaging protocols or study populations, and better repeatability in large tumours compared with smaller tumours, indicating that ADC is a robust imaging metric with excellent repeatability in extra-cranial soft-tissue tumours.

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