Abstract #2920

Combining DW- and DCE-MRI for treatment response assessment in patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy

Sophie E. Heethuis¹, Lucas Goense^1,2, Peter S.N. van Rossum^1,2, Alicia S. Borggreve^1,2, Stella Mook¹, Francine E. Voncken³, Richard van Hillegersberg², Jelle P. Ruurda², Gert J. Meijer¹, Jan J.W. Lagendijk¹, and Astrid L.H.M.W. van Lier¹

¹Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Radiotherapy, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam

Neoadjuvant chemoradiotherapy prior to surgery is often used for treatment of patients with esophageal cancer. Potential benefit could be gained developing a patient tailored treatment, especially for the 29% of the patients who show a pathologic complete response. In this prospective multicenter study it was investigated whether combining DCE- and DW-MRI, which both showed potential for response prediction in previous studies, yields complementary information. It was found that the combination of DCE- and DW-MRI can increase the predictive values and reaches higher ROC_AUC.

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