We perform a quantitative histological evaluation of a range of MRI techniques in their ability to probe glioblastoma invasion in a mouse model. Using 3-D histological stacks co-registered with MRI slices allows to achieve high values in Dice, sensitivity and specificity tests (>90%). This approach enables to go beyond the standard evaluation tests, performing direct voxel-to-voxel comparison between MRI and histology, and facilitating the development of multi-parametric analysis models. We also identified promising methods for detecting low tumour concentration regions at the invasion limits.
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