Abstract #2933

Measurement of human cardiac intracellular pH in vivo using long TR 31P-MRS with adiabatic excitation at 7T

Ladislav Valkovic^1,2, William T Clarke¹, Lucian AB Purvis¹, Matthew D Robson¹, Stefan Neubauer¹, and Christopher T Rodgers¹

¹Oxford Centre for Clinical MR Research (OCMR), RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

Determination of human cardiac intracellular pH using ³¹P-MRS is challenging as the resonance frequency of Pi is concealed by a close resonating 2,3-DPG signal originating from blood. Common short TR and low-flip angle scan used for cardiac ³¹P-MRS increase the effective SNR/time, but can additionally suppress the Pi signal intensity. We have investigated the feasibility of detecting cardiac Pi and calculating intracellular pH of human heart using long TR 3D-CSI examination with adiabatic excitation at 7T. Comparison to short TR acquisition was performed using interleaved TR measurements. We report robust and repeatable detection of Pi signal in 100% of subjects.

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