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Abstract #2946

Protocol for investigating in vivo Glucose Metabolism in Human Breast Cancer by 13C MRS at 7T

Sergey Cheshkov1,2, Ivan E. Dimitrov1,3, Joseph Rispoli4, Jiaming Cui5, Mary McDougall4,5, Steve Wright4,5, Stephen Seiler2, A. Dean Sherry1,2,6, and Craig R. Malloy1,2,7

1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Philips Medical Systems, Cleveland, OH, United States, 4Biomedical Engineering, Texas A&M University, TX, United States, 5Electrical Engineering, Texas A&M University, TX, United States, 6Chemistry, University of Texas at Dallas, TX, United States, 7Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

Upregulated glucose uptake in cancer is often observed and can be monitored with a radiolabeled analogue of glucose, 18FDG, with detection by PET, however, a well-known constraint is its ionizing radiation. Additionally, except for the trapping of that glucose analogue, PET does not provide information about subsequent glucose metabolism. Here, we demonstrated the feasibility of a simple glucose infusion protocol that allows detection of glucose oxidation in human breast cancer in vivo via 7T 13C MRS. The [U-13C]glucose infusion is performed outside of the magnet making the protocol significantly more suitable for patients compared to previous approaches that required prolonged 13C substrate infusions inside the scanner.

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