Meeting Banner
Abstract #2968

Lactate is associated with tumour grading in breast cancer – An ex vivo study on whole breast tumours using multiple quantum coherence (MQC) MRS

Sai Man Cheung1, Ehab Husain2,3, Yazan Masannat3,4, Klaus Wahle3,5, Steven D Heys3,4, and Jiabao He1

1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, 2Pathology Department, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 3School of Medicine, University of Aberdeen, Aberdeen, United Kingdom, 4Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 5Strathclyde Institute of Pharmacy and Biological Sciences, Glasgow, United Kingdom

Breast cancer is associated with increased lactate production in tumour, known as Warburg effect, that is postulated to enhance cancer cell survival advantage and invasiveness. However, current evidence, mainly based on xenografted animal models or biopsy results, remains controversial, where non-identical biological environments are compared to humans, or partial sampling error may play a role. We therefore examined the role of lactate concentration in whole human breast tumour, and hypothesised that there is a difference in lactate concentration between grade II and III breast cancer. To extract lactate under overwhelming lipid signal, MQC MRS was optimised for robust measurement.

This abstract and the presentation materials are available to members only; a login is required.

Join Here