Abstract #2975

GABA concentration measurements in infants without sedation

Ryan J. Larsen¹, Borjan Gagoski², Marie Drottar², Thea Francel², Alana Matos², Clarisa Carruthers², Catherine Vu², Jonathan Litt³, Bradley P. Sutton^1,4, and Ellen Grant⁵

¹Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Boston Children's Hospital, Harvard Medical School, Boston, MA, United States, ³Beth Israel Deaconess Medical Center, Boston, MA, United States, ⁴Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Boston Children's Hospital, Harvard Medical School, Boston, MA

We report measurements of GABA concentration in infants without sedation using the MEshcher-Garwood (MEGA) sequence. Single-voxel measurements were performed in 114 infants at approximately one month and/or three months of age. Quantification is performed with water scaling, and concentration values are reported in units of mM of NMR-visible water in the brain. For the two scan times, we found the inter-subject coefficient of variation (CV) of GABA to be 8% and 9%, respectively. Average GABA concentration values are 7% higher for the 3 month scan than the 1 month scan, indicating a gradual increase in GABA concentration after birth.

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