Abstract #2988

Metabolic Assessment of a Migraine Model using Relaxation-Enhanced 1H Spectroscopy at Ultra-High Field

Nastaren Abad^1,2, Jens T. Rosenberg¹, Tangi Roussel³, Dillon Grice², Michael G. Harrington⁴, and Samuel Colles Grant^1,2

¹Center for Interdisciplinary Magnetic Resonance, National High Magnetic Field Laboratory, Tallahassee, FL, United States, ²Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, ³Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, ⁴Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA, United States

This study evaluates biochemical and metabolic imbalances that may result in a collection of dysfunctional pathways that are distinct in migraineurs. The high sensitivity and spectral dispersion available to ¹H MRS at 21.1 T expanded metabolic profiling in an animal model of migraine to include total creatine (tCr), choline (Cho), N-acetyl-aspartate (NAA), myoinositol (mI), lactate (Lac), taurine (Tau), aspartate (Asp), Glx, a mixture of glutamate, glutamine and GABA, and Gly, the latter identified as a mixture of glycine, glutamine, and glutamate. For the migraine analogue, Lac, Gly and Tau increased while tCr decreased temporally and in comparison to saline controls.

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