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Abstract #2993

Influence of age-specific macromolecular pattern on MRS quantification

Malgorzata Marjanska1, J Riley McCarten2, Dinesh Deelchand1, Laura S Hemmy2, and Melissa Terpstra1

1Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Geriatric Research Education and Clinical Center, Minneapolis VA Medical Center, MN, United States

The resonances originating from high-molecular weight macromolecules (MM) underlie those of metabolites in brain 1H NMR spectra. In humans, MM content and MM pattern have been shown to depend on age of the subject. In this project, the influence of age-specific MM pattern on MR quantification was investigated. The age-associated differences in the MM pattern have a major influence on the quantification of metabolite concentrations in the aging brain which might lead to different interpretation of the data. This important finding suggests that the age-specific MM spectrum should be used in the basis set to obtain accurate concentrations of metabolites.

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