Whole brain temperature mapping is of great interest for investigating traumatic brain injuries. Single-voxel-spectroscopy (SVS) and CSI approaches provides limited spatial coverage in the brain, whereas 3D Echo-planar spectroscopic imaging (EPSI), covers the entire brain for investigating temperature and metabolism in traumatic brain injury and other studies . Our study focuses on calibration and validation of the temperature measurement in brain phantoms using EPSI and SVS at pre-clinical and clinical scanners, to study and analysis of whole brain temperature in rodents and humans.
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