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Abstract #3011

Dual spectral analysis for metabolite quantification in the presence of lipids and macromolecules

Peter J Lally1,2, Alan Bainbridge3, and Sudhin Thayyil1,2

1Imperial College London, London, United Kingdom, 2Imperial College Healthcare NHS Trust, London, United Kingdom, 3Medical Physics & Bioengineering, University College London Hospitals NHS Trust, London, United Kingdom

In this study, we aim to reduce the bias inherent in fitting short echo time spectra by performing a two-point saturation recovery experiment. At both points lipid and macromolecule magnetisation is excited from an approximately fully relaxed state and so this signal component is unchanged, thus the fitting model can be constrained. We show that this may be an advantageous strategy in comparison to other common techniques, reducing bias where fitting spectra with narrow linewidths.

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