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Abstract #3012

GABA editing with reduced sensitivity to B1 inhomogeneity and improved detectability at 7T using MEGA-LASER

Pallab Bhattacharyya1, Mark Lowe1, and Ovidiu Andronesi2

1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Radiology, Massachusetts General Hospital, Charlestown, MA, United States

GABA spectroscopy is performed at 7T in vitro and in vivo using MEGA-PRESS and MEGA-LASER sequences. MEGA-LASER is shown to be much less sensitive to B1 inhomogeneity, and having higher signal intensity than MEGA-PRESS. Relative inter- and intra-sequence variabilities with respect to B1 inhomogeneity and regional variation are reported. Higher signal intensity in MEGA-LASER is attributed to reduced chemical shift displacement artifact and less signal loss resulting from spatial effects in phase evolution of J-coupled GABA.

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