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Abstract #3037

Simultaneous Visualization of Hyperpolarized Fluorinated Amino Acids by Multi Chemical Shift Selective 19F MRI

Tuba Güden-Silber1, Jürgen Schrader2, and Ulrich Flögel1

1Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany, 2Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany

We demonstrate the induction of 19F photo-chemically induced dynamic nuclear polarization (photo-CIDNP) in 19F MR imaging experiments. To this end, we made use of laser-induced hyperpolarization in a system consisting of flavin mononucleotide as a photosensitizer and the fluorinated aromatic amino acids tyrosine and tryptophan, respectively. The induction of 19F photo-CIDNP led to an extensive 19F signal enhancement which could be exploited for simultaneous imaging of both amino acids by 19F multi chemical shift-selective imaging within 20 s. Hence, our approach resulted in a substantial improvement of the intrinsically low 19F MR sensitivity for mono-fluorinated amino acids.

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