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Abstract #3048

High Resolution MEMRI Reveals the Purkinje Cell Layer as the Source of Contrast in the Mouse Cerebellum

Harikrishna Rallapalli1,2, Brian J Nieman3, Aidin Arbabi3, Dulcie Vousden3, Jason P Lerch3, and Daniel H Turnbull1,2

1Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, United States, 2Biomedical Imaging Graduate Program and Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada

Imaging the developing mouse brain with conventional MRI is challenging. Manganese-enhanced MRI (MEMRI) has the potential to provide a noninvasive, in vivo approach for analyzing mutant phenotypes in the early postnatal mouse cerebellum. We present preliminary data generated using a CryoProbe (Bruker) suggesting that the primary source of Mn contrast in the mouse cerebellum is the Purkinje cell layer.

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