Apoptosis is involved in many pathological processes. Early detection of treatment-induced apoptosis in malignant tumors is clinically useful for a decision making in therapeutic strategy. Phosphatidylserine (PS) expressed on the cell membrane is known to be a marker of apoptosis which can be detected by probes with Annexin V. In this study, we newly synthesized USPIO-conjugated Annexin V and investigated its potential in the use in apoptosis imaging in both in vitro and in vivo studies.
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