Abstract #3073

Improved tracking and quantification of SPIO-labeled cells using bSSFP with compressed sensing TurboSPI

Zoe O'Brien-Moran^1,2, Marie-Laurence Tremblay¹, Christa Davis¹, James Rioux^1,2,3, and Kimberly Brewer^1,2,3,4

¹Biomedical Translational Imaging Centre (BIOTIC), Halifax, NS, Canada, ²Physics, Dalhousie University, Halifax, NS, Canada, ³Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, ⁴Microbiology, Dalhousie University, Halifax, NS, Canada

Understanding immune cell behaviour is important for evaluating therapeutic response in pre-clinical models. We monitor cell migration in a mouse model of cervical cancer by labeling cells with superparamagnetic iron oxide (SPIO). Simultaneous pre-clinical PET/MRI confirmed that the balanced steady-state free precession (bSSFP) sequence lacks specificity to SPIO-labeled cells within the tumor. We tested TurboSPI, a multi-echo single point imaging technique with compressed sensing that provides high temporal resolution 3D R₂* mapping in under 45 minutes. These maps exhibit superior SPIO specificity compared to bSSFP images and enabled us to do both qualitative and quantitative cell tracking.

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