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Abstract #3075

19F MR-Imaging of acute thrombi using a clinically relevant perfluorocarbon nanoemulsion

Sebastian Temme1, Christoph Jacoby2, Christoph Grapentin3, Jürgen Schrader1, and Ulrich Flögel1

1Molecular Cardiology, University of Düsseldorf, Düsseldorf, Germany, 2Division of Cardiology, Pulmonology and Vascular Medicine, University of Düsseldorf, Düsseldorf, Germany, 3Pharmaceutical Technology and Biopharmacy, University of Freiburg, Freiburg i. Br.

Exact localization of acute thrombi is still a serious problem in the clinical setting. Here we show the feasibility of artefact-free 19F MR-imaging using clinically relevant PFOB-nanoemulsions functionalized with an α2-antiplasmin peptide, specific for early thrombi. Utilizing the isolated CF3-peak of PFOB in combination with a conventional 19F RARE sequence is suitable for specific and artefact-free imaging of acute thrombi in vitro and also in vivo.

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