Inversion-recovery (IR) prepared SPACE was recently proposed as a whole-brain intracranial vessel wall imaging technique. This work aimed to investigate the feasibility of accelerating the scan from 8 min to <5 min using compressed sensing (CS). A prototype CS IR-SPACE sequence was implemented on a 3T system. Wavelet sparse regularization (λ) and iteration (Iter) were optimized for the scenario of sampling 15% of k-space data based on a volunteer study. Image quality was visually comparable between CS IR-SPACE and regular IR-SPACE scans. In addition, CS IR-SPACE and IR-SPACE showed comparable lesion delineation quality in patients despite markedly different scan times.