Meeting Banner
Abstract #3157

Regions of spared hypertrophy in pressure overloaded hearts promote severe systolic dysfunction as assessed by comprehensive cardiovascular magnetic resonance

Sebastian Maximilian Haberkorn1,2, Joachim Schmitt3, Christoph Jacoby1, Jürgen Schrader2,4, Malte Kelm1,4, and Uli Flögel2,4

1Department of Cardiology, University Hospital Duesseldorf, Duesseldorf, Germany, 2Department of Molecular Cardiology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, 3Heinrich-Heine University Duesseldorf, Department of Pharmacology and Clinical Pharmacology, Duesseldorf, Germany, 4Cardiovascular Research Institute, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany

Regional heterogeneity of contractile function was described in patients with left ventricular (LV) hypertrophy, suggesting a predominant impairment of areas with distinct hypertrophy. Heterogeneity of myocardial hypertrophy therefore may contribute to global and regional abnormalities of LV function. Here, we systematically investigated the spatial and temporal patterning of myocardial hypertrophy in response to experimental pressure overload by cardiovascular MRI. Surprisingly, we identified a specific basolateral LV segment that is frequently spared from the development of myocardial hypertrophy and promotes systolic dysfunction. Moreover, the initial LV geometry and the vascular topology seemed to limit the extent of adaptation to pressure overload.

This abstract and the presentation materials are available to members only; a login is required.

Join Here