Purpose: To evaluate whether DWI allow discrimination of thoracoabdominal neuroblastic tumors of various histological types and differentiation grades. Materials and Methods: The DWI scans of the thoracoabdominal neuroblastic tumors in twenty-five children were retrospectively evaluated. DWI was performed with 2 b values of 0 and 800s/mm2 on a 3.0T MR scanner. Results: In the 25 cases, ganglioneuroma (GN) was in 3 cases, ganglioneuroblastoma (GNB) -Intermixed in 4, GNB-Nodular in 3 and neuroblastoma (NB) in 15. The ADC values of the NBs were significantly lower than those of GNs/GNBs (P＜.001). The ADC of GNB-Nodular/NB was significantly less than that of GN/GNB-Intermixed (p<0.0001). In GNB-Nodular and NB, the tumors with poorly differentiated and undifferentiated lesions (n=12) had significantly smaller ADC than those with differentiated composition (n=6) (P=.0012). Conclusion: ADC of DWI is highly valuable for discriminating thoracoabdominal neuroblastic tumors of different histological types and subtypes.