Fat signal fraction (FF) and R2* mapping as well as MRS of the liver were performed in 201 patients. Results for FF from imaging and MRS were compared to a newly defined parameter T1_FF. T1_FF was calculated from a variable flip angle 3D GRE technique with 2 echo times. Based on the Dixon method, T1 maps from in-phase and from water signal were calculated and T1_FF was deduced. T1_FF correlated well with FF and might be used as a novel estimation of fat fraction. Relevant discrepancies were seen in cases with high R2*.