Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver worldwide. Microvascular invasion (MVI) is a significant predictor of prognosis and preoperative prediction of MVI is useful for deciding treatment strategy. We assessed the value of ADC and IVIM texture parameters in predicting the MVI of HBV-related HCCs by whole tumor analysis. Our results showed that ADC and IVIM derived texture parameters were useful for the prediction of MVI of HCCs. Texture analysis of ADC and IVIM is a promising method for predicting MVI of HBV-related HCC.